The silk industry is important for south China's rural economy. Leaves of mulberry (Morus spp.) are used for silkworm production. Hubei province is one of the main silk-producing provinces in China. The objectives of this research were to survey the fertilization practices in the mulberry-producing regions in the province and to determine the best nutrition-management practice for mulberry plantations. A survey and a series of field experiments with N, P, K, and micronutrients were conducted from 2001 to 2002. In addition, a silkworm-growth experiment was also conducted by feeding leaves harvested from various fertilization treatments. The results indicate that poor soil fertility and unbalanced fertilization were the main factors limiting mulberry-leaf yield and quality in Hubei province. Nitrogen fertilization of mulberry has reached a high level (454 kg ha(-1) y(-1)) in Hubei province, but P- and K-fertilization rates have not been matched with N-fertilization rates as farmers are not aware of the significance of P and K. Balanced fertilization showed positive nutrient interactions with respect to mulberry yield and quality. Potassium application increased yield and quality (protein and sugar concentration) of mulberry leaves. Silkworm growth and cocoon quality were improved when silkworms were fed with the leaves derived from K-fertilized plants in comparison with those taken from control plots. Application of Mg, S, and B also significantly improved leaf sugar, essential and total amino acid concentrations, but did not increase leaf yield significantly. It is concluded that a fertilizer dose of 375 kg N ha(-1), 66 kg P ha(-1), and 125 kg K ha(-1) is suitable for the cultivation of mulberry in the Hubei province along with Mg, S, and B, wherever necessary, for the improvement of yield and quality of mulberry leaves.